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Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures.

Maria E KaufmanOmar R VayaniKelley MooreAlexandre ChlenskiTong WuSang Mee LeeAmi Vijay DesaiChuan HeSusan L CohnMark A Applebaum
Published in: Cancer research communications (2024)
Adrenergic (ADRN) and mesenchymal (MES) lineages are distinct biologic cell types in neuroblastoma. We defined ADRN and MES specific genes and found that high-risk, ADRN tumors harboring elevated T-cell inflammation signatures had superior overall survival. Our findings bolster support for further developing immunotherapy-based approaches for children with high-risk neuroblastoma.
Keyphrases
  • oxidative stress
  • genome wide
  • bone marrow
  • stem cells
  • rheumatoid arthritis
  • young adults
  • cell therapy
  • type diabetes
  • mesenchymal stem cells
  • metabolic syndrome
  • transcription factor
  • weight loss
  • bioinformatics analysis