Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures.
Maria E KaufmanOmar R VayaniKelley MooreAlexandre ChlenskiTong WuSang Mee LeeAmi Vijay DesaiChuan HeSusan L CohnMark A ApplebaumPublished in: Cancer research communications (2024)
Adrenergic (ADRN) and mesenchymal (MES) lineages are distinct biologic cell types in neuroblastoma. We defined ADRN and MES specific genes and found that high-risk, ADRN tumors harboring elevated T-cell inflammation signatures had superior overall survival. Our findings bolster support for further developing immunotherapy-based approaches for children with high-risk neuroblastoma.