Thiourea-Mediated Stereospecific Deoxygenation of Cyanoepoxides to Access Highly Diastereopure Alkenyl Nitriles.
Yujie ZhangShukui ShiZhanhui YangPublished in: The Journal of organic chemistry (2024)
A practical and efficient protocol for synthesis of >99% diastereopure Z - and E -alkenyl nitriles is developed, through tetramethylthiourea-mediated stereospecific deoxygenation of respective cis - and trans -cyanoepoxides in ethanol. The desired products are obtained in excellent yields.
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