Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9.

Daniel EhrsamSandro SieberMouhssin OufirFabiola PortaMatthias Hamburger Joerg Huwyler Henriette E Meyer Zu Schwabedissen

Published in: Bioconjugate chemistry (2020)

taken together, we confirmed increased MMP9 in several cancer tissues (cervical, esophageal, lung, and brain) compared to healthy tissue and showed the effectiveness of MMP9-labile prodrug in in vitro tests.

Keyphrases

cell migration
randomized controlled trial
papillary thyroid
systematic review
drug delivery
white matter
squamous cell
cancer therapy
multiple sclerosis
young adults
blood brain barrier
drug release
cerebral ischemia
lymph node metastasis
brain injury