Sex-dependent differences in mouse placental gene expression following a maternal high fat diet.
Matthew R GraceNeeta L VoraLisa SmeesterSarah Dotters-KatzRebecca FryVictoria Bae-JumpKim BoggessPublished in: American journal of perinatology (2023)
In female compared to male pups in utero exposure to HFD upregulated placental gene expression in 15 genes predicted to be regulated by insulin. Sex-specific differences in placental expression of these genes should be further investigated.
Keyphrases
- high fat diet
- gene expression
- adipose tissue
- insulin resistance
- dna methylation
- genome wide
- type diabetes
- poor prognosis
- bioinformatics analysis
- genome wide identification
- metabolic syndrome
- glycemic control
- genome wide analysis
- skeletal muscle
- physical activity
- binding protein
- long non coding rna
- weight loss
- high speed