Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach.

Na WangSiran WuJing ZhaoMin ChenJiaoxia ZengGuofang LuJiaojiao WangJian ZhangJunye LiuYong Quan Shi

Published in: Cellular oncology (Dordrecht) (2021)

Our findings indicate that FXR may be responsible for a series of molecular changes in gastric cells after BA treatment, and that the FXR/SNAI2/miR-1 axis exhibits a crucial role in BA-induced progression of IM. Blocking the FXR-oriented axis may provide a promising approach for IM or even GC treatment.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
induced apoptosis
long noncoding rna
signaling pathway
cell cycle arrest
cell death
binding protein