Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain.
Qu XingAntonio CibelliGreta Luyuan YangPreeti DohareQing-Hua LiEliana ScemesFang-Xia GuanDavid C SprayPublished in: Military Medical Research (2024)
The present study revealed that neuronal Panx1 is a prominent driver of peripheral sensitivity in the setting of inflammatory pain through cell-autonomous effects on neuronal excitability. This hyperexcitability dependence on neuronal Panx1 contrasts with inflammatory orofacial pain, where similar studies revealed a prominent role for glial Panx1. The apparent differences in Panx1 expression in neuronal and non-neuronal TG and DRG cells are likely responsible for the distinct impact of these cell types in the two pain models.
Keyphrases
- chronic pain
- neuropathic pain
- single cell
- pain management
- cerebral ischemia
- oxidative stress
- poor prognosis
- spinal cord injury
- magnetic resonance imaging
- computed tomography
- stem cells
- bone marrow
- subarachnoid hemorrhage
- mesenchymal stem cells
- postoperative pain
- long non coding rna
- transcranial direct current stimulation