Biocompatible Chitosan Oligosaccharide Modified Gold Nanorods as Highly Effective Photothermal Agents for Ablation of Breast Cancer Cells.
Panchanathan ManivasaganSubramaniyan BharathirajaMadhappan Santha MoorthySudip MondalThanh Phuoc NguyenHyehyun KimThi Tuong Vy PhanKang Dae LeeJunghwan OhPublished in: Polymers (2018)
Photothermal therapy (PTT) using biocompatible nanomaterials have recently attracted much attention as a novel candidate technique for cancer therapy. In this work we report the performance of newly synthesized multidentate chitosan oligosaccharide modified gold nanorods (AuNRs-LA-COS) as novel agents for PTT of cancer cells due to their excellent biocompatibility, photothermal stability, and high absorption in the near-infrared (NIR) region. The AuNRs-LA-COS exhibit a strong NIR absorption peak at 838 nm with a mean length of 26 ± 3.1 nm and diameter of 6.8 ± 1.7 nm, respectively. The temperature of AuNRs-LA-COS rapidly reached 52.6 °C for 5 min of NIR laser irradiation at 2 W/cm². The AuNRs-LA-COS had very low cytotoxicity and exhibited high efficiency for the ablation of breast cancer cells in vitro. The tumor-bearing mice were completely ablated without tumor recurrence after photothermal treatment with AuNRs-LA-COS (25 µg/mL) under laser irradiation. In summary, this study demonstrated that AuNRs-LA-COS with laser irradiation as novel agents pave an alternative way for breast cancer therapy and hold great promise for clinical trials in the near future.
Keyphrases
- cancer therapy
- photodynamic therapy
- drug delivery
- drug release
- breast cancer cells
- clinical trial
- high efficiency
- fluorescence imaging
- ionic liquid
- high speed
- type diabetes
- adipose tissue
- metabolic syndrome
- working memory
- randomized controlled trial
- skeletal muscle
- hyaluronic acid
- atrial fibrillation
- gold nanoparticles
- study protocol
- optic nerve
- optical coherence tomography
- combination therapy