Necroptosis-dependent immunogenicity of cisplatin: implications for enhancing the radiation-induced abscopal effect.

Gabriele Niedermann Kateryna Onyshchenko Liqun Wang Simone Gaedicke Anca-Ligia Grosu Elke Firat Gabriele Niedermann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Cisplatin induces antitumor immunity through necroptosis-mediated ICD. Our findings may help explain the benefits of cisplatin in chemo(radio)immunotherapies and develop clinical trials to investigate whether cisplatin enhances the abscopal effect in patients.

Keyphrases

radiation induced
clinical trial
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
radiation therapy
photodynamic therapy
prognostic factors
randomized controlled trial
squamous cell carcinoma
combination therapy