Efficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate.

Yuki YamanashiMika OhmichiYusuke Ohmichi Tatsunori IkemotoYoung-Chang AraiYohei MaruyamaShun OtsukaShuichi HiraiMunekazu NaitoMasataka Deie

Published in: Journal of inflammation research (2021)

Our results imply that MTX administration improves pain-related behaviors and suppresses expression of pain-related mRNAs in the DRG and knee joint; however, MTX is not expected to prevent cartilage degeneration in MIA-induced OA in rat knee.

Keyphrases

knee osteoarthritis
chronic pain
pain management
neuropathic pain
oxidative stress
poor prognosis
total knee arthroplasty
diabetic rats
spinal cord
extracellular matrix
low dose
long non coding rna