Sodium, Added Sugar and Saturated Fat Intake in Relation to Mortality and Cardiovascular Disease Events in Adults: Canadian National Nutrition Survey Linked with Vital Statistics and Health Administrative Databases.

This study aimed to determine whether higher intakes of sodium, added sugars and saturated fat are prospectively associated with all-cause mortality and cardiovascular disease (CVD) incidence and mortality in a diverse population. The nationally-representative Canadian Community Health Survey (CCHS)-Nutrition 2004 was linked with the Canadian Vital Statistics - Death Database and the Discharge Abstract Database (2004-2011). Outcomes were all-cause mortality and CVD incidence and mortality. There were 1,722 mortality cases within 115,566 person-years of follow-up (median (IQR) of 7.48 (7.22-7.70) years). There was no statistically significant association between sodium density or energy from saturated fat and all-cause mortality or CVD events for all models investigated. The association of usual percentage of energy from added sugars and all-cause mortality was significant in the base model with participants consuming 11.47% of energy from added sugars having 1.34 (95% CI: 1.01-1.77) times higher risk of all-cause mortality compared to those consuming 4.17% of energy from added sugars. Overall, our results did not find statistically significant associations between the three nutrients and risk of all-cause mortality or CVD events at the population level in Canada. Large-scale linked national nutrition datasets may not have the discrimination to identify prospective impacts of nutrients on health measures.