Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma.

Ahmed IdbaihMichael CanneyLisa BelinCarole DesseauxAlexandre VignotGuillaume BouchouxNicolas AsquierBruno Law-YeDelphine LeclercqAnne BisseryYann De RyckeClementine TroschLaurent CapelleMarc SansonKhe Hoang-XuanCaroline DehaisCaroline HouillierFlorence Laigle-DonadeyBertrand MathonArthur AndréCyril LafonJean-Yves ChapelonJean-Yves DelattreAlexandre Carpentier

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

SonoCloud-1 treatments were well tolerated and may increase the effectiveness of systemic drug therapies, such as carboplatin, in the brain without inducing neurotoxicity.See related commentary by Sonabend and Stupp, p. 3750.

Keyphrases

blood brain barrier
cerebral ischemia
randomized controlled trial
magnetic resonance imaging
systematic review
drug induced
phase ii study
resting state
white matter
adverse drug
brain injury
ultrasound guided
functional connectivity
multiple sclerosis
phase iii