CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases.
Jennifer NhieuYu-Lung LinLi-Na WeiPublished in: Nutrients (2022)
In this review, we discuss the emerging role of Cellular Retinoic Acid Binding Protein 1 (CRABP1) as a mediator of non-canonical activities of retinoic acid (RA) and relevance to human diseases. We first discuss the role of CRABP1 in regulating MAPK activities and its implication in stem cell proliferation, cancers, adipocyte health, and neuro-immune regulation. We then discuss an additional role of CRABP1 in regulating CaMKII activities, and its implication in heart and motor neuron diseases. Through molecular and genetic studies of Crabp1 knockout (CKO) mouse and culture models, it is established that CRABP1 forms complexes with specific signaling molecules to function as RA-regulated signalsomes in a cell context-dependent manner. Gene expression data and CRABP1 gene single nucleotide polymorphisms (SNPs) of human cancer, neurodegeneration, and immune disease patients implicate the potential association of abnormality in CRABP1 with human diseases. Finally, therapeutic strategies for managing certain human diseases by targeting CRABP1 are discussed.
Keyphrases
- endothelial cells
- gene expression
- cell proliferation
- induced pluripotent stem cells
- healthcare
- rheumatoid arthritis
- pluripotent stem cells
- heart failure
- mental health
- genome wide
- dna methylation
- squamous cell carcinoma
- stem cells
- newly diagnosed
- atrial fibrillation
- oxidative stress
- risk assessment
- copy number
- ejection fraction
- skeletal muscle
- machine learning
- papillary thyroid
- bone marrow
- prognostic factors
- disease activity
- lymph node metastasis
- systemic lupus erythematosus
- pi k akt
- climate change
- artificial intelligence