LncRNA ANRIL Promotes Glucose Metabolism and Proliferation of Colon Cancer in a High-Glucose Environment and is Associated with Worse Outcome in Diabetic Colon Cancer Patients.

Hala MosaadSally M ShalabyNevertety M MahmoudMona M AhmedAlaa FayedHassan R AshourWalaa Sarhan

Published in: Asian Pacific journal of cancer prevention : APJCP (2024)

A high-glucose environment can increase the tumor-promoting effect of ANRIL. ANRIL can promote glucose metabolism and colon cancer proliferation by downregulating miR-186-5p with subsequent upregulation of glycolysis enzymes expression and inhibition of apoptosis.

Keyphrases

high glucose
endothelial cells
poor prognosis
signaling pathway
long non coding rna
oxidative stress
endoplasmic reticulum stress
type diabetes
cell cycle arrest
cell proliferation
cell death
pi k akt
wound healing
long noncoding rna