Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies.

Lambros TselikasThierry de BaereThomas IsoardoSandrine SusiniKarine Ser-Le RouxMélanie PolrotJulien AdamMathieu RouanneLaurence ZitvogelLaurence MoineFréderic DeschampsAurélien Marabelle

Published in: Journal for immunotherapy of cancer (2021)

Pickering emulsions of ethiodized oil and PLGA is an innovative radiopaque delivery platform that does not alter the functionality of anti-CTLA4 immune checkpoint antibodies. Beyond local anti-CTLA4 applications, these emulsions might be used with other therapeutic molecules for optimal intratumorous or intra-arterial delivery of novel cancer immunotherapies.

Keyphrases

papillary thyroid
high throughput
young adults
lymph node metastasis
childhood cancer
oxide nanoparticles