Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.

Petra Popovics Wisam N Awadallah Sarah E KohrtThomas C CaseNicole L MillerEmily A RickeWei HuangMarisol Ramirez-SolanoQi LiuChad M VezinaRobert J MatusikWilliam A Ricke Magdalena M Grabowska

Published in: The Prostate (2020)

OPN is more abundant in prostates of men with S-BPH compared to men with I-BPH. OPN secretion is stimulated by proinflammatory cytokines, and OPN acts directly on stromal cells to drive the synthesis of proinflammatory mRNAs. Pharmacological manipulation of prostatic OPN may have the potential to reduce LUTS by inhibiting both inflammatory and fibrotic pathways.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
poor prognosis
middle aged
oxidative stress
signaling pathway
systemic sclerosis
prostate cancer
binding protein
human health
risk assessment