Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.

Published in: Journal of diabetes investigation (2017)

Gut microbiota dysbiosis reduces expression of GLP-1 receptor (GLP-1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP-1-induced nitric oxide (NO) production through a pattern recognition receptor (PRR)-dependent mechanism, hence preventing activation of the gut-brain-periphery axis for control of insulin secretion and gastric emptying.

Keyphrases

nitric oxide synthase
nitric oxide
poor prognosis
hydrogen peroxide
high glucose
cerebral ischemia
diabetic rats
white matter
resting state
oxidative stress
long non coding rna
multiple sclerosis
subarachnoid hemorrhage