Current Concepts in the Orthopaedic Management of Duchenne Muscular Dystrophy.
Matthew WeintraubArjun GuptaAhmed KhokharMichael VivesNeil KaushalPublished in: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2024)
Duchenne muscular dystrophy (DMD), a genetic condition marked by progressive muscle degeneration, presents notable orthopaedic challenges, especially scoliosis, which deteriorates patients' quality of life by affecting sitting balance and complicating cardiac and respiratory functions. Current orthopaedic management strategies emphasize early intervention with corticosteroids to delay disease progression and the use of surgical spinal fusion to address severe scoliosis, aiming to enhance sitting balance, alleviate discomfort, and potentially extend patient lifespan. Despite advancements, optimal management requires ongoing research to refine therapeutic approaches, ensuring improved outcomes for patients with DMD. This review synthesizes recent findings on surgical and nonsurgical interventions, underscoring the importance of a multidisciplinary approach tailored to the dynamic needs of patients with DMD.
Keyphrases
- duchenne muscular dystrophy
- muscular dystrophy
- randomized controlled trial
- end stage renal disease
- multiple sclerosis
- skeletal muscle
- physical activity
- prognostic factors
- spinal cord
- case report
- gene expression
- metabolic syndrome
- genome wide
- type diabetes
- dna methylation
- peritoneal dialysis
- smoking cessation
- spinal cord injury
- patient reported outcomes
- weight loss
- quality improvement