Three functional variants in the NLRP3 gene are associated with susceptibility and clinical characteristics of systemic lupus erythematosus.

Naeim EhteshamMaryam Zare RafieEmran EsmaeilzadehMohammad DehaniSaeideh DavarMeysam MosallaeiBahram PakzadTahereh GhorashiHossein DarvishMohsen Soosanabadi

Published in: Lupus (2021)

This study demonstrates a substantial association between NLRP3 polymorphisms with increased risk, clinical symptoms, and the severity of disease activity of SLE.

Keyphrases

systemic lupus erythematosus
disease activity
rheumatoid arthritis
rheumatoid arthritis patients
ankylosing spondylitis
copy number
juvenile idiopathic arthritis
nlrp inflammasome
genome wide
physical activity