ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Peter A B WarkPrabuddha S PathinayakeGerard KaikoKristy NicholAyesha AliLing ChenErika N SutantoLuke W GarrattSukhwinder S SohalWenying LuMathew Suji EapenChristopher OldmeadowNathan BartlettAndrew ReidPunnam VeeratiAlan C-Y HsuKevin LooiThomas IosifidisStephen M StickPhilip M HansbroAnthony KicicPublished in: Respirology (Carlton, Vic.) (2021)
Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.
Keyphrases
- poor prognosis
- end stage renal disease
- chronic obstructive pulmonary disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- lung function
- coronavirus disease
- angiotensin ii
- binding protein
- sars cov
- peritoneal dialysis
- long non coding rna
- angiotensin converting enzyme
- patient reported outcomes
- risk factors
- middle aged
- patient reported