Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.
Fumiya MoribeMomoko NishikoriTsuyoshi TakashimaDaiki TaniyamaNobuyuki OnishiHiroshi ArimaHiroyuki SasanumaRemi AkagawaFathi ElloumiShunichi TakedaYves PommierEiichi MoriiAkifumi Takaori-KondoJunko MuraiPublished in: PloS one (2021)
The expression of SLFN11 is epigenetically suppressed in normal GCBs and GCB-derived lymphomas. GCB-derived lymphomas with low SLFN11 expression can be treated by the combination of epigenetic modifiers and cytosine arabinoside.