DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome.
Kayla GuidryVarshini VasudevarajaKristen E LabbeHussein MohamedJonathan SerranoBrett W GuidryMichael DeLorenzoHua ZhangJiehui DengSoumyadip SahuChristina AlmonteAndre L MoreiraAristotelis TsirigosThales PapagiannakopoulosHarvey I PassMatija SnuderlKwok-Kin WongPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our results demonstrate that DNA methylation signatures can stratify LUAD into clinically relevant subtypes, and thus such classification of LUAD at the time of resection may lead to better methods in predicting tumor recurrence and therapy responses.