Aristotelis Tsirigos (A Tsirigos)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 97

Top Venues

Nature cancer

Cancer discovery

Nature communications

Science advances

NYU School of Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

NYU School of Medicine Mar 1o 2014

United States

Associate Professor (Research) of Pathology :: Pathology

Publications

Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P Davis, Nicolas Stransky, Gromoslaw A Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H Sterman, John T Poirier, Ben Neel, Kwok-Kin Wong, Luis A Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N Segal, Andre L Moreira, Harvey I Pass, Aristotelis Tsirigos
Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma. Nature communications 14 (1) (2023)
Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Aristotelis Tsirigos, Esteban Orlando Mazzoni, Danny Reinberg
Novel Chromatin Insulating Activities Uncovered upon Eliminating Known Insulators in vivo . bioRxiv : the preprint server for biology (2023)
Gregor Werba, Daniel Weissinger, Emily A Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H Sherman, Amanda W Lund, Theodore H Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M Simeone
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nature communications 14 (1) (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Gregor Werba, Daniel Weissinger, Emily A Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H Sherman, Amanda W Lund, Theodore H Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M Simeone
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nature communications 14 (1) (2023)
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature biotechnology (2023)
Ray G Pillai, Sarah E Leboeuf, Yuan Hao, Connie New, Jenna L E Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie N Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I Sayin, Kamal M Khanna, Kwok-Kin Wong, Robert Wild, Aristotelis Tsirigos, John T Poirier, Charles M Rudin, Shawn M Davidson, Sergei B Koralov, Thales Papagiannakopoulos
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer. bioRxiv : the preprint server for biology (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Gregor Werba, Daniel Weissinger, Emily A Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H Sherman, Amanda W Lund, Theodore H Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M Simeone
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nature communications 14 (1) (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Dylan Murphy, Eralda Salataj, Dafne Campigli Di Giammartino, Javier Rodriguez-Hernaez, Andreas Kloetgen, Vidur Garg, Erin Char, Christopher M Uyehara, Ly-Sha Ee, UkJin Lee, Matthias Stadtfeld, Anna-Katerina Hadjantonakis, Aristotelis Tsirigos, Alexander Polyzos, Effie Apostolou
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nature structural & molecular biology (2023)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2023)
Jue Feng, Pei-Feng Hsu, Eduardo Esteva, Rossella Labella, Yueyang Wang, Alireza Khodadadi-Jamayran, Joseph Nicholas Pucella, Cynthia Z Liu, Arnaldo A Arbini, Aristotelis Tsirigos, Stavroula Kousteni, Boris Reizis
Haplodeficiency of the 9p21 Tumor Suppressor Locus Causes Myeloid Disorders Driven by the Bone Marrow Microenvironment. Blood (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Aristotelis Tsirigos, Esteban Orlando Mazzoni, Danny Reinberg
Novel Chromatin Insulating Activities Uncovered upon Eliminating Known Insulators in vivo . bioRxiv : the preprint server for biology (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Ali Rashidfarrokhi, Ray G Pillai, Yuan Hao, Warren L Wu, Burcu Karadal-Ferrena, Sofia G Dimitriadoy, Michael Cross, Anna H Yeaton, Shih Ming Huang, Arjun J Bhutkar, Alberto Herrera, Sahith Rajalingam, Makiko Hayashi, Kuan-Lin Huang, Eric Bartnicki, Anastasia-Maria Zavitsanou, Corrin A Wohlhieter, Sarah E Leboeuf, Ting Chen, Cynthia Loomis, Valeria Mezzano, Ruth Kulicke, Fred P Davis, Nicolas Stransky, Gromoslaw A Smolen, Charles M Rudin, Andre L Moreira, Kamal M Khanna, Harvey I Pass, Kwok-Kin Wong, Shohei Koide, Aristotelis Tsirigos, Sergei B Koralov, Thales Papagiannakopoulos
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. bioRxiv : the preprint server for biology (2023)
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature biotechnology (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Jane A Skok, Theodore Sakellaropoulos, Catherine Do, Guimei Jiang, Giulia Cova, Peter Meyn, Dacia Dimartino, Sitharam Ramaswami, Adriana Heguy, Aristotelis Tsirigos
MethNet: a robust approach to identify regulatory hubs and their distal targets in cancer. Research square (2023)
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature biotechnology (2023)
Lindsey H Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V Nayak, Paulo El Parente, Margaux Sambon, Pablo J Atria, Mohamed A E Ali, Lukasz Witek, Alesha B Castillo, Christopher Y Park, Ralf H Adams, Aristotelis Tsirigos, Sophie M Morgani, Philipp Leucht
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging. Bone research 11 (1) (2023)
Gregor Werba, Daniel Weissinger, Emily A Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H Sherman, Amanda W Lund, Theodore H Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M Simeone
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nature communications 14 (1) (2023)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2023)
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer discovery (2023)
Eileen Mary Boyle, Patrick Blaney, James H Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc J Braunstein, Louis Williams, Avital Tenenbaum, Ariel M Siegel, Xiaoyi Chen, Gaurav Varma, Jason Avigan, Alexander Li, Monica Jinsi, David Kaminetzky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even Holth Rustad, Carl Ola Landgren, Francesco Maura, Brian A Walker, Michael A Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E Davies, Gareth J Morgan
Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Veronica Davalos, Claudia D Lovell, Richard Von Itter, Igor Dolgalev, Praveen Agrawal, Gillian Baptiste, David J Kahler, Elena Sokolova, Sebastian Moran, Laia Piqué, Eleazar Vega-Saenz de Miera, Barbara Fontanals-Cirera, Alcida Karz, Aristotelis Tsirigos, Chi Yun, Farbod Darvishian, Heather C Etchevers, Iman Osman, Manel Esteller, Markus Schober, Eva Hernando-Monge
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma. Nature communications 14 (1) (2023)
Naoko Yamaguchi, Ernest Whanwook Chang, Ziyan Lin, Akshay Shekhar, Lei Bu, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Yiyun Cen, Colin K L Phoon, Ivan P Moskowitz, David S Park
An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract. Circulation (2023)
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature biotechnology (2023)
Gregor Werba, Daniel Weissinger, Emily A Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H Sherman, Amanda W Lund, Theodore H Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M Simeone
Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment. Nature communications 14 (1) (2023)
Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T Gutierrez-Diaz, Marina V Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E Velu, Kavitha Sarma, Basil B Mattamana, Byoung-Kyu Cho, Rebecca C Obeng, Young Ah Goo, Philip W Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia. Science advances 8 (3) (2022)
Anna H Yeaton, Geraldine Cayanan, Sanam Loghavi, Igor Dolgalev, Emmett M Leddin, Christian E Loo, Hedieh Torabifard, Deedra Nicolet, Jingjing Wang, Kate Corrigan, Varvara Paraskevopoulou, Daniel T Starczynowski, Eric Wang, Omar Abdel-Wahab, Aaron D Viny, Richard M Stone, John C Byrd, Olga A Guryanova, Rahul M Kohli, Gerardo Andrés Cisneros, Aristotelis Tsirigos, Ann-Kathrin Eisfeld, Iannis Aifantis, Maria Guillamot
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation. Cancer discovery 12 (10) (2022)
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qiang-Hu Wang, Jie Yang, Aram S Modrek, Hua Zhang, Aristotelis Tsirigos, P Andrew Futreal, Giulio F Draetta, Roel G W Verhaak, Erik P Sulman
Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF V600E inhibition resistance in melanoma. Cell discovery 8 (1) (2022)
Rana S Moubarak, Ana de Pablos-Aragoneses, Vanessa Ortiz-Barahona, Yixiao Gong, Michael Gowen, Igor Dolgalev, Sorin A A Shadaloey, Diana Argibay, Alcida Karz, Richard Von Itter, Eleazar Carmelo Vega-Sáenz de Miera, Elena Sokolova, Farbod Darvishian, Aristotelis Tsirigos, Iman Osman
The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis. Science advances 8 (7) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R Brown, Allison M L Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-Kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran, Benjamin G Neel
Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer. Cancer discovery 12 (4) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Nicolas Coudray, Aristotelis Tsirigos
Deep learning links histology, molecular signatures and prognosis in cancer. Nature cancer 1 (8) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Kayla Guidry, Varshini Vasudevaraja, Kristen E Labbe, Hussein Mohamed, Jonathan Serrano, Brett W Guidry, Michael DeLorenzo, Hua Zhang, Jiehui Deng, Soumyadip Sahu, Christina Almonte, Andre L Moreira, Aristotelis Tsirigos, Thales Papagiannakopoulos, Harvey I Pass, Matija Snuderl, Kwok-Kin Wong
DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (17) (2022)
Andrea Lopez, Denis E Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nature communications 13 (1) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Qi Jin, Blanca T Gutierrez-Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Van Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat C Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science advances 8 (49) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Jie Yang, Qiang-Hu Wang, Ze-Yan Zhang, Lihong Long, Ravesanker Ezhilarasan, Jerome M Karp, Aristotelis Tsirigos, Matija Snuderl, Benedikt Wiestler, Wolfgang Wick, Yinsen Miao, Jason T Huse, Erik P Sulman
DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomas. Nature communications 13 (1) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer 4 (1) (2022)
Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Varun Narendra, Gary LeRoy, Edgar Gonzalez-Buendia, Jane A Skok, Aristotelis Tsirigos, Esteban Orlando Mazzoni, Danny Reinberg
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters. Nature genetics 54 (2) (2022)
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A Obeng, Aristotelis Tsirigos, Richard M Stone, John C Byrd, Stanley B Pounds, William L Carroll, Tanja A Grüber, Ann-Kathrin Eisfeld, Iannis Aifantis
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature cancer (2022)
Piotr Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, Kody P Mansfield, Brandon Hsieh, Douglas E Biancur, Samantha B Larsen, Michael Cammer, Dongqing Li, Ning Xu Landén, Cynthia Loomis, Adriana Heguy, Anastasia N Tikhonova, Aristotelis Tsirigos, Shruti Naik
Interleukin-17 governs hypoxic adaptation of injured epithelium. Science (New York, N.Y.) 377 (6602) (2022)
Hai Hu, Alireza Khodadadi-Jamayran, Igor Dolgalev, Hyunwoo Cho, Sana Badri, Luis A Chiriboga, Briana Zeck, Miguel Lopez de Rodas, Catríona M Dowling, Kristen Labbe, Jiehui Deng, Ting Chen, Hua Zhang, Paul Zappile, Ze Chen, Beatrix Ueberheide, Angeliki Karatza, Han Han, Michela Ranieri, Sittinon Tang, George Jour, Iman Osman, Antje Sucker, Dirk Schadendorf, Aristotelis Tsirigos, Kurt A Schalper, Vamsidhar Velcheti, Hsin-Yi Huang, Yujuan Jin, Hongbin Ji, John T Poirier, Fei Li, Kwok-Kin Wong
Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Cancer immunology research 9 (11) (2021)
Palaniraja Thandapani, Andreas Kloetgen, Matthew T Witkowski, Christina Glytsou, Anna K Lee, Eric Wang, Jingjing Wang, Sarah E LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos, Iannis Aifantis
Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature 601 (7893) (2021)
Kwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A Zebala, Dean Y Maeda, James G Christensen, Peter Olson, Argus Athanas, Cynthia A Loomis, Aristotelis Tsirigos, Kwok-Kin Wong, Benjamin G Neel
Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC. Cancer discovery (2021)
Maria Grigoriou, Aggelos Banos, Aikaterini Hatzioannou, Andreas Kloetgen, Panagiotis Kouzis, Despoina Aggouraki, Roubini Zakopoulou, Giorgos Bamias, Eva Kassi, Dimitrios Mavroudis, Aristotelis Bamias, Dimitrios T Boumpas, Aristotelis Tsirigos, Helen Gogas, Themis Alissafi, Panayotis Verginis
Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors. Cancer immunology research 9 (7) (2021)
Vangelis Vergetis, Dimitrios Skaltsas, Vassilis G Gorgoulis, Aristotelis Tsirigos
Assessing Drug Development Risk Using Big Data and Machine Learning. Cancer research 81 (4) (2020)
Nan Zhang, Julen Mendieta-Esteban, Alessandro Magli, Karin C Lilja, Rita C R Perlingeiro, Marc A Marti-Renom, Aristotelis Tsirigos, Brian David Dynlacht
Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology. Nature communications 11 (1) (2020)
Nicholas Frazzette, Alireza Khodadadi-Jamayran, Nicole Doudican, Alexis Santana, Diane Felsen, Anna C Pavlick, Aristotelis Tsirigos, John A Carucci
Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma. NPJ precision oncology 4 (2020)
Nevin Yusufova, Andreas Kloetgen, Matt Teater, Adewola Osunsade, Jeannie M Camarillo, Christopher R Chin, Ashley S Doane, Bryan J Venters, Stephanie Portillo-Ledesma, Joseph Conway, Jude M Phillip, Olivier Elemento, David W Scott, Wendy Béguelin, Jonathan D Licht, Neil L Kelleher, Louis M Staudt, Arthur I Skoultchi, Michael-Christopher Keogh, Effie Apostolou, Christopher E Mason, Marcin Imielinski, Tamar Schlick, Yael David, Aristotelis Tsirigos, C David Allis, Alexey A Soshnev, Ethel Cesarman, Ari M Melnick
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature 589 (7841) (2020)
Shella Saint Fleur-Lominy, Nikki A Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H Choi, Xiaotu Ma, Jun J Yang, Stephen P Hunger, Elizabeth Raetz, Richard C Harvey, Cheryl Willman, Mignon L Loh, Patrick A Brown, Kylie M Getz, Cem Meydan, Christopher E Mason, Aristotelis Tsirigos, William L Carroll
Evolution of the Epigenetic Landscape in Childhood B Acute Lymphoblastic Leukemia and Its Role in Drug Resistance. Cancer research 80 (23) (2020)
Marie Jo Halaby, Kebria Hezaveh, Sara Lamorte, M Teresa Ciudad, Andreas Kloetgen, Bethany L MacLeod, Mengdi Guo, Ankur Chakravarthy, Tiago da Silva Medina, Stefano Ugel, Aristotelis Tsirigos, Vincenzo Bronte, David H Munn, Trevor J Pugh, Daniel D De Carvalho, Marcus O Butler, Pamela S Ohashi, David G Brooks, Tracy L McGaha
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment. Science immunology 4 (42) (2020)
Ariadna Giró-Perafita, L Luo, A Khodadadi-Jamayran, M Thompson, B Akgol Oksuz, Aristotelis Tsirigos, B D Dynlacht, I Sánchez, F J Esteva
LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer. NPJ breast cancer 6 (2020)
Loredana Moro, Daniele Simoneschi, Emma Kurz, Arnaldo A Arbini, Shaowen Jang, Nicoletta Guaragnella, Sergio Giannattasio, Wei Wang, Yu-An Chen, Geoffrey Pires, Andrew Dang, Elizabeth Hernandez, Payal Kapur, Ankita Mishra, Aristotelis Tsirigos, George Miller, Jer-Tsong Hsieh, Michele Pagano
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis. Nature cell biology 22 (9) (2020)
Joanna Pierro, Jason Saliba, Sonali Narang, Gunjan Sethia, Shella Saint Fleur-Lominy, Ashfiyah Chowdhury, Anita Qualls, Hannah Fay, Harrison L Kilberg, Takaya Moriyama, Tori J Fuller, David T Teachey, Kjeld Schmiegelow, Jun J Yang, Mignon L Loh, Patrick A Brown, Jinghui Zhang, Xiaotu Ma, Aristotelis Tsirigos, Nikki A Evensen, William L Carroll
The NSD2 p.E1099K Mutation Is Enriched at Relapse and Confers Drug Resistance in a Cell Context-Dependent Manner in Pediatric Acute Lymphoblastic Leukemia. Molecular cancer research : MCR 18 (8) (2020)
Paul Johannet, Nicolas Coudray, Douglas M Donnelly, George Jour, Irineu Illa-Bochaca, Yuhe Xia, Douglas B Johnson, Lee Wheless, James Randall Patrinley, Sofia Nomikou, David L Rimm, Anna C Pavlick, Jeffrey S Weber, Judy Zhong, Aristotelis Tsirigos, Iman Osman
Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (1) (2020)
Yalu Zhou, Cuijuan Han, Eric Wang, Adam H Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T Gutierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna A Kuchmiy, Limin Sun, George Yacu, Szymon K Filip, Qi Jin, Yoh-Hei Takahashi, David R Amici, Emily Jane Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso, Panagiotis Ntziachristos
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia. Cancer discovery 10 (9) (2020)
Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, Hai Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, Francesco Boccalatte, Hua Zhong, Elisabeth Paietta, Thomas Trimarchi, Yixing Zhu, Pieter Van Vlierberghe, Giorgio Ga Inghirami, Timothee Lionnet, Iannis Aifantis, Aristotelis Tsirigos
Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nature genetics 52 (4) (2020)
Jun-Chieh J Tsay, Benjamin G Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L Bessich, Robert L Smith, Harald Sauthoff, Kevin Felner, Ray G Pillai, Anastasia-Maria Zavitsanou, Sergei B Koralov, Valeria Mezzano, Cynthia A Loomis, Andre L Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N Rom, Daniel H Sterman, Harvey I Pass, Jose C Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos, Leopoldo N Segal
Lower Airway Dysbiosis Affects Lung Cancer Progression. Cancer discovery 11 (2) (2020)
Ramona Bledea, Varshini Vasudevaraja, Seema Patel, James Stafford, Jonathan Serrano, Gianna Esposito, Lilian M Tredwin, Nina Goodman, Andreas Kloetgen, John G Golfinos, David Zagzag, Britta Weigelt, A John Iafrate, Erik P Sulman, Andrew S Chi, Snjezana Dogan, Jorge Sergio Reis-Filho, Sarah Chiang, Dimitris Placantonakis, Aristotelis Tsirigos, Matija Snuderl
Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers. Scientific reports 9 (1) (2019)
Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, Theodore Sakellaropoulos, Gunjan Sethia, Andreas Kloetgen, MacIntosh Cornwell, Sourya Bhattacharyya, Ferhat Ay, Richard A Bonneau, Aristotelis Tsirigos, Jane A Skok
NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains. Nature communications 10 (1) (2019)
Aikaterini Hatzioannou, Aggelos Banos, Theodore Sakelaropoulos, Constantinos Fedonidis, Maria-Sophia Vidali, Maren Köhne, Kristian Händler, Louis Boon, Ana Henriques, Vasiliki Koliaraki, Panagiotis Georgiadis, Jerome Zoidakis, Aikaterini Termentzi, Marc Beyer, Triantafyllos Chavakis, Dimitrios Boumpas, Aristotelis Tsirigos, Panayotis Verginis
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion. Nature immunology 21 (1) (2019)
Xufeng Chen, Christina Glytsou, Hua Zhou, Sonali Narang, Denis E Reyna, Andrea Lopez, Theodore Sakellaropoulos, Yixiao Gong, Andreas Kloetgen, Yoon Sing Yap, Eric Wang, Evripidis Gavathiotis, Aristotelis Tsirigos, Raoul Tibes, Iannis Aifantis
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. Cancer discovery 9 (7) (2019)
Maria Guillamot, Dahmane Ouazia, Igor Dolgalev, Stephen T Yeung, Nikos Kourtis, Yuling Dai, Kate Corrigan, Luna Zea-Redondo, Anita Saraf, Laurence Florens, Michael P Washburn, Anastasia N Tikhonova, Marina Malumbres, Yixiao Gong, Aristotelis Tsirigos, Christopher Park, Christopher Barbieri, Kamal M Khanna, Luca Busino, Iannis Aifantis
The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nature immunology 20 (9) (2019)
Dafne Campigli Di Giammartino, Andreas Kloetgen, Alexander P Polyzos, Yiyuan Liu, Daleum Kim, Dylan Murphy, Abderhman Abuhashem, Paola Cavaliere, Boaz Aronson, Veevek Shah, Noah Dephoure, Matthias Stadtfeld, Aristotelis Tsirigos, Effie Apostolou
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nature cell biology 21 (10) (2019)
Fei Li, Qingyuan Huang, Troy A Luster, Hai Hu, Hua Zhang, Billy Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jiehui Deng, Michela Ranieri, Zhaoyuan Fang, Val Pyon, Catríona M Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Papagiannakopoulos, Peter S Hammerman, Vamsidhar Velcheti, Gordon J Freeman, Jun Qi, George Miller, Kwok-Kin Wong
In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma. Cancer discovery 10 (2) (2019)
Frederick Licciardi, Tenzin Lhakhang, Yael G Kramer, Yutong Zhang, Adriana Heguy, Aristotelis Tsirigos
Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles. Scientific reports 8 (1) (2018)
Nikos Kourtis, Charalampos Lazaris, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R Jimenez, Jasper Mullenders, Yixiao Gong, Thomas Trimarchi, Kamala Bhatt, Hai Hu, Liza Shrestha, Alberto Ambesi-Impiombato, Michelle Kelliher, Elisabeth Paietta, Gabriela Chiosis, Monica L Guzman, Adolfo A Ferrando, Aristotelis Tsirigos, Iannis Aifantis
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nature medicine 24 (8) (2018)
Rahul S Shinde, Kebria Hezaveh, Marie Jo Halaby, Andreas Kloetgen, Ankur Chakravarthy, Tiago da Silva Medina, Reema Deol, Kieran P Manion, Yuriy Baglaenko, Maria Eldh, Sara Lamorte, Drew Wallace, Sathi Babu Chodisetti, Buvana Ravishankar, Haiyun Liu, Kapil Chaudhary, David H Munn, Aristotelis Tsirigos, Michael Madaio, Susanne Gabrielsson, Zahi Touma, Joan Wither, Daniel D De Carvalho, Tracy L McGaha
Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nature immunology 19 (6) (2018)
Marissa Spino, Sylvia C Kurz, Luis A Chiriboga, Jonathan Serrano, Briana Zeck, Namita Sen, Seema Patel, Guomiao Shen, Varshini Vasudevaraja, Aristotelis Tsirigos, Carter M Suryadevara, Joshua D Frenster, Kensuke Tateishi, Hiroaki Wakimoto, Rajan Jain, Howard A Riina, Theodore P Nicolaides, Erik P Sulman, Daniel P Cahill, John G Golfinos, Kumiko Isse, Laura R Saunders, David Zagzag, Dimitris G Placantonakis, Matija Snuderl, Andrew S Chi
Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (4) (2018)
Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nature communications 9 (1) (2018)
Akshay Shekhar, Xianming Lin, Bin Lin, Fang-Yu Liu, Jie Zhang, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Lei Bu, Glenn I Fishman, David S Park
ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes. Scientific reports 8 (1) (2018)
Dennis O Adeegbe, Shengwu Liu, Maureen M Hattersley, Michaela Bowden, Chensheng W Zhou, Shuai Li, Raven Vlahos, Michael Grondine, Igor Dolgalev, Elena V Ivanova, Max M Quinn, Peng Gao, Peter S Hammerman, James E Bradner, J Alan Diehl, Anil K Rustgi, Adam J Bass, Aristotelis Tsirigos, Gordon J Freeman, Huawei Chen, Kwok-Kin Wong
BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer. Cancer immunology research 6 (10) (2018)
Nicolas Coudray, Paolo Santiago Ocampo, Theodore Sakellaropoulos, Navneet Narula, Matija Snuderl, David Fenyö, Andre L Moreira, Narges Razavian, Aristotelis Tsirigos
Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nature medicine 24 (10) (2018)
Yixiao Gong, Hsuan-Ting Huang, Yu Liang, Thomas Trimarchi, Iannis Aifantis, Aristotelis Tsirigos
lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets. BMC genomics 18 (1) (2017)
Charalampos Lazaris, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC genomics 18 (1) (2017)

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Aristotelis Tsirigos (A Tsirigos)