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Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.

Christopher MullallyKeith A StubbsVan C ThaiAnandhi AnandanStephanie BartleyMartin J ScanlonGary A JarvisConstance M JohnKatherine Y L LimCourtney M SullivanMitali Sarkar-TysonAlice VrielinkCharlene M Kahler
Published in: The Journal of antimicrobial chemotherapy (2022)
Small molecules have been designed that bind to EptA, inhibit addition of phosphoethanolamine to lipid A and can sensitize N. gonorrhoeae to killing by macrophages.
Keyphrases
  • fatty acid
  • signaling pathway