Laser-assisted topical delivery of vismodegib reduces hedgehog gene expression in human basal cell carcinomas in vivo.
Uffe Hoegh OlesenKristian Kåber PedersenKatrine Togsverd-BoEdyta BiskupAnni Linnet NielsenMalene JackerottGael ClergeaudThomas Lars AndresenMerete HaedersdalPublished in: Lasers in surgery and medicine (2024)
A single AFL-assisted topical application of vismodegib resulted in clinically relevant intratumoral drug concentrations and significant reductions in hedgehog pathway gene expressions.
Keyphrases
- basal cell carcinoma
- gene expression
- endothelial cells
- dna methylation
- single cell
- wound healing
- genome wide
- cell therapy
- pluripotent stem cells
- high grade
- induced pluripotent stem cells
- copy number
- stem cells
- emergency department
- adverse drug
- mesenchymal stem cells
- high resolution
- electronic health record
- drug induced