A unicentric cross-sectional observational study on chronic intestinal inflammation in total colonic aganglionosis: beware of an underestimated condition.

M ErculianiF PoluzziG MottadelliE FeliciNovi MlM CaracciaA GrandiS CasellaL GiacomettiG MontobbioI CeccheriniE Di MarcoC BonarettiR BiassoniM SquillarioA PietrantoniV VillanacciAlessio Pini Prato

Published in: Orphanet journal of rare diseases (2023)

Our study demonstrated an impressive 10-folds higher incidence of chronic inflammation in TCSA. Up to 50% of patients may develop IBD-like lesions postoperatively. Nonetheless, we failed in identifying specific risk factors to be used to implement prevention strategies. Based on the results of our study, we suggest screening all TCSA patients with retrograde ileoscopy regardless of FC/OFB values. The frequency of endoscopic assessments and the role of FC/OFB screening in prompting endoscopy is yet to be determined.

Keyphrases

risk factors
cross sectional
oxidative stress
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
ultrasound guided
drug induced