Our data provide definitive evidence that these compounds, characteristic of Abn-CBD receptor pharmacology, are acting via GPR18 in BV-2 microglia. A fuller understanding of the hitherto unidentified cannabinoid receptors such as GPR18; their molecular interactions with endogenous ligands; and how phytocannabinoids influence their signaling is vital if we are to comprehensively assess the function of the endogenous cannabinoid signaling system in human health and disease.
Keyphrases
- human health
- cell migration
- risk assessment
- inflammatory response
- lps induced
- fatty acid
- lipopolysaccharide induced
- neuropathic pain
- climate change
- diabetic rats
- electronic health record
- big data
- squamous cell carcinoma
- machine learning
- radiation therapy
- spinal cord injury
- hyaluronic acid
- binding protein
- rectal cancer