Uncovering Actions of Type 3 Deiodinase in the Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).
Rafael Aguiar MarschnerAna Cristina RoginskiRafael Teixeira RibeiroLarisse LongoMário Reis Álvares-da-SilvaSimone Magagnin WajnerPublished in: Cells (2023)
Induced D3, triggered by changes in the REDOX state, decreases T3 availability and hepatic mitochondrial capacity. The Krebs cycle enzymes were altered as well as endoplasmic reticulum stress. Taken together, these results shed new light on the role of D3 metabolism in MAFLD.