Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19.

Tian-Zi WenTian-Ran LiXin-Yu ChenHe-Yuan ChenShuai WangWen-Juan FuShi-Qi XiaoJie LuoRui TangJia-Le JiJia-Feng HuangZhi-Cheng HeTao LuoHong-Liang ZhaoCong ChenJing-Ya MiaoQin NiuYan WangXiu-Wu BianXiao-Hong Yao

Published in: Metabolism: clinical and experimental (2024)

Critical COVID-19 was characterized by potentiated adrenal steroidogenesis, associated with increased inflammation, enhanced differentiation and elevated dual-ZG/ZF identity cells, alongside suppressed corticosteroid responsiveness. These alterations implied the reduced effectiveness of conventional corticosteroid therapy and underscored the need for evaluation of the adrenal axis and corticosteroid sensitivity.

Keyphrases

coronavirus disease
sars cov
induced apoptosis
randomized controlled trial
systematic review
cell cycle arrest
signaling pathway
mesenchymal stem cells
endoplasmic reticulum stress
cell proliferation
cell therapy