Movement disorders in hereditary spastic paraplegia (HSP): a systematic review and individual participant data meta-analysis.

Seyed-Mohammad FereshtehnejadPhilip A SalehLais M OliveiraNeha PatelSuvorit BhowmickGerard SaranzaLorraine V Kalia

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

This systematic IPD-level meta-analysis provides the largest data on genotype-phenotype associations in HSP-MD. Several clinically relevant phenotypic differences were found between various genotypes, which can possibly facilitate diagnosis in resource-limited settings.

Keyphrases

systematic review
meta analyses
heat shock protein
electronic health record
heat stress
heat shock
molecular dynamics
randomized controlled trial
oxidative stress
deep learning
botulinum toxin