UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.

Brittney S HarringtonRahul KamdarFranklin NingSoumya KorrapatiMichael W CaminearLidia F HernandezDonna ButcherElijah F EdmondsonNadia TraficanteJoy Hendleynull nullMadeline GoughRebecca RogersRohan LourieJyoti ShettyBao TranFathi ElloumiAbdalla AbdelmaksoudMadhu Lal NagKrystyna Mazan-MamczarzCarrie D HouseJohn D HooperChristina M Annunziata

Published in: Journal of experimental & clinical cancer research : CR (2023)

These data show that modulation of UGDH expression in ovarian cancer reveals distinct roles for UGDH in the C1/Mesenchymal and C4/Differentiated molecular subtypes of EOC, influencing the tumor microenvironmental composition. UGDH is a strong potential therapeutic target in TICs, for the treatment of EOC, particularly in patients with the mesenchymal molecular subtype.

Keyphrases

bone marrow
stem cells
induced apoptosis
poor prognosis
cell cycle arrest
signaling pathway
big data
long non coding rna
human health
pi k akt