Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
null nullNathan I ShapiroIvor S DouglasRoy G BrowerSamuel M BrownMatthew C ExlineAdit A GindeMichelle N GongColin K GrissomDouglas HaydenCatherine L HoughWeixing HuangTheodore J IwashynaAlan E JonesAkram KhanPoying LaiKathleen D LiuChadwick D MillerKatherine OldmixonPauline K ParkTodd W RiceNancy RingwoodMatthew W SemlerJay S SteingrubDaniel TalmorB Taylor ThompsonDonald M YealyWesley H SelfPublished in: The New England journal of medicine (2023)
Among patients with sepsis-induced hypotension, the restrictive fluid strategy that was used in this trial did not result in significantly lower (or higher) mortality before discharge home by day 90 than the liberal fluid strategy. (Funded by the National Heart, Lung, and Blood Institute; CLOVERS ClinicalTrials.gov number, NCT03434028.).