Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy.
Tibor RákAndrea Kovács-ValasekEtelka PöstyéniAdrienne CsutakRóbert GábrielPublished in: Cells (2023)
Diabetes mellitus affects carbohydrate homeostasis but also influences fat and protein metabolism. Due to ophthalmic complications, it is a leading cause of blindness worldwide. The molecular pathology reveals that nuclear factor kappa B (NFκB) has a central role in the progression of diabetic retinopathy, sharing this signaling pathway with another major retinal disorder, glaucoma. Therefore, new therapeutic approaches can be elaborated to decelerate the ever-emerging "epidemics" of diabetic retinopathy and glaucoma targeting this critical node. In our review, we emphasize the role of an improvement of lifestyle in its prevention as well as the use of phytomedicals associated with evidence-based protocols. A balanced personalized therapy requires an integrative approach to be more successful for prevention and early treatment.
Keyphrases
- diabetic retinopathy
- nuclear factor
- optical coherence tomography
- toll like receptor
- signaling pathway
- optic nerve
- health information
- healthcare
- public health
- pi k akt
- cardiovascular disease
- lymph node
- adipose tissue
- metabolic syndrome
- mental health
- weight loss
- social media
- cancer therapy
- immune response
- cataract surgery
- type diabetes
- combination therapy
- stem cells
- single molecule
- protein protein
- insulin resistance
- fatty acid
- mesenchymal stem cells
- binding protein
- risk assessment
- replacement therapy
- small molecule
- glycemic control
- oxidative stress