Impaired longitudinal systolic-diastolic coupling and cardiac response to exercise in patients with hypertrophic cardiomyopathy.
James P MacNamaraWilliam M TurlingtonKatrin A DiasChristopher M HearonErika IveyVincent A DelgadoTiffany L BrazileDenis J WakehamAslan T TurerMark S LinkBenjamin D LevineSatyam SarmaPublished in: Echocardiography (Mount Kisco, N.Y.) (2024)
Systolic-diastolic coupling was impaired in patients with HCM and was associated with fitness and the cardiac response to exercise. Inefficient S-D coupling may link insufficient stroke volume generation, diastolic dysfunction, and exercise intolerance in HCM.