Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis.
Ji Min ParkShin KimSung Uk BaeSang Jun ByunIncheol SeoHye-Won LeePublished in: Journal of Korean medical science (2023)
CRT is an important issue in LARC and is a major aspect of treatment. Thus, the Nrf2/Keap1 expression may be a potential predictor of preoperative therapeutic resistance. The Nrf2-Keap1 modulators that interact with each other may also be effectively applicable to CRT effect in LARC.
Keyphrases
- locally advanced
- rectal cancer
- nuclear factor
- neoadjuvant chemotherapy
- squamous cell carcinoma
- toll like receptor
- phase ii study
- radiation therapy
- oxidative stress
- poor prognosis
- cardiac resynchronization therapy
- small molecule
- protein protein
- patients undergoing
- early stage
- radiation induced
- combination therapy
- binding protein
- clinical trial
- lymph node
- immune response
- drug induced
- study protocol
- inflammatory response
- replacement therapy