Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Gregory ParsonageKevin CuthbertsonNaima EndeshNicoletta MurcianoAdam J HymanCharlotte H RevillOleksandr V PovstyanEulashini Chuntharpursat-BonMarjolaine DebantMelanie J LudlowT Simon FutersLaeticia LichtensteinJacob A KinsellaFiona BartoliMaria Giustina RotordamNadine BeckerAndrea BrüggemannRichard FosterDavid J BeechPublished in: British journal of pharmacology (2022)
4-Benzoic acid modification of Yoda1 improves PIEZO1 agonism. We suggest naming this new modulator Yoda2. It should be a useful tool compound in physiological assays and facilitate efforts to identify a binding site. Such compounds may have therapeutic potential, for example in diseases linked genetically to PIEZO1 such as lymphatic dysplasia.
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