Alcohol drinking, DNA methylation and psychiatric disorders: A multi-omics Mendelian randomization study to investigate causal pathways.

Xiaoqiang ShiMing D LiJianhua YaoMing D LiZhongli Yang

Published in: Addiction (Abingdon, England) (2024)

Pathological drinking behavior and alcohol-related DNA methylation appear to have a causal effect on psychiatric disorders. The expression of genes regulated by the alcohol-related DNA methylation sites may underpin this association.

Keyphrases

dna methylation
alcohol consumption
genome wide
gene expression
poor prognosis
copy number
single cell
long non coding rna
transcription factor
bioinformatics analysis