Heat shock protein 70 is induced by pepsin via MAPK signaling in human nasal epithelial cells.

Jing WangYu ZhaoJianjun RenYang XuWen YangLei LeiYongbo ZhengZhang QinxiuZhaoping He

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2019)

Pepsin, even under neutral pH 7.0, increases the expression of HSP70 in HNEpCs by activating the JNK/MAPK signaling pathway. Increased HSP70 may be the protective mechanism when pepsin presents in the other parts of the body.

Keyphrases

heat shock protein
signaling pathway
pi k akt
induced apoptosis
heat shock
epithelial mesenchymal transition
endothelial cells
poor prognosis
induced pluripotent stem cells
chronic rhinosinusitis
cell death
binding protein
heat stress