Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency.
Shiqiao YeCankun WangZhaohui XuHui LinXiaoping WanYang YuSubhodip AdhicaryJoe Z ZhangYang ZhouChun LiuMatthew AlonzoJianli BiAngelina Ramirez-NavarroIsabelle DeschenesQin MaVidu GargJoseph C WuMing-Tao ZhaoPublished in: Circulation research (2022)
variants lead to biased differentiation of first heart field progenitors, blocked ventricular-like cardiomyocyte differentiation, and defective cardiomyocyte proliferation, which collaboratively contribute to left ventricular hypoplasia in hypoplastic left heart syndrome.
Keyphrases
- left ventricular
- heart failure
- endothelial cells
- angiotensin ii
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- acute myocardial infarction
- single cell
- high glucose
- aortic stenosis
- atrial fibrillation
- mitral valve
- left atrial
- copy number
- cell proliferation
- cell therapy
- induced pluripotent stem cells
- case report
- gene expression
- pluripotent stem cells
- catheter ablation
- replacement therapy
- mesenchymal stem cells
- aortic valve
- dna methylation
- transcatheter aortic valve replacement