STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells.

Harrison M PenroseAkemi KatsuradaKayoko MiyataMaki UrushiharaRyousuke Satou

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)

These results demonstrate that while interferon-γ increases both angiotensinogen and monocyte chemoattractant protein 1 expression, STAT1 plays an opposing role in the regulation of each factor in mesangial cells.

Keyphrases

induced apoptosis
high glucose
endothelial cells
dendritic cells
cell cycle arrest
cell proliferation
poor prognosis
endoplasmic reticulum stress
oxidative stress
signaling pathway
diabetic rats
binding protein