Do Serum Urate-associated Genetic Variants Influence Gout Risk in People Taking Diuretics? Analysis of the UK Biobank.
Ravi K NarangGreg GambleAmanda J Phipps-GreenRuth ToplessMurray CadzowLisa K StampTony R MerrimanNicola DalbethPublished in: The Journal of rheumatology (2020)
In people taking diuretics, SU-associated genetic variants contribute strongly to gout risk, with a similar effect to that observed in those not taking a diuretic. These findings suggest that the contribution of genetic variants is not restricted to people with "primary" gout, and that genetic variants can play an important role in gout susceptibility in the presence of other risk factors.