Exosomal AP000439.2 from clear cell renal cell carcinoma induces M2 macrophage polarization to promote tumor progression through activation of STAT3.
Tianyi ShenSuqin MiaoYulin ZhouXiaoming YiSong XueBowen DuChaopeng TangLe QuDian FuRuipeng JiaHaowei HePublished in: Cell communication and signaling : CCS (2022)
Exosomes from ccRCC deliver AP000439.2 to promote M2 macrophage polarization via STAT3, thus enhancing ccRCC progression, indicating exosomal AP000439.2 might be a novel therapeutic target in ccRCC. Video Abstract.