LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy.

Sunny Mai Alan Hodges Hui-Ming Chen Jilu Zhang Yi-Ling Wang Yongbin Liu Fumiko Nakatsu Xiaoxuan Wang Jing Fang Yitian Xu Vitaliy Davidov Kyeongah Kang Sai Ravi Pingali Siddhartha Ganguly Masataka Suzuki Marina Y Konopleva Brooke Prinzing Youli Zu Stephen Gottschalk Yong Lu Shu-Hsia Chen Ping-Ying Pan

Published in: Cancer research (2023)

LILRB3 regulates differentiation and proliferation in acute myeloid leukemia and can be targeted with monoclonal antibodies and CAR T cells to suppress leukemia growth.

Keyphrases

cell therapy
acute myeloid leukemia
stem cells
allogeneic hematopoietic stem cell transplantation
mesenchymal stem cells
signaling pathway
cancer therapy
bone marrow
drug delivery
acute lymphoblastic leukemia