The Lung Allograft Microbiome Associates with Pepsin, Inflammation, and Primary Graft Dysfunction.
John E McGinnissSamantha A WhitesideRebecca A DeekAurea Simon-SoroJevon Graham-WootenMichelle OysterMelanie D BrownEdward CantuJoshua M DiamondHongzhe LiJason D ChristieFrederic D BushmanRonald G CollmanPublished in: American journal of respiratory and critical care medicine (2022)
Lung allografts that develop PGD have a microbiome enriched in anaerobic oropharyngeal taxa, elevated gastric pepsin, and hyperinflammatory phenotype. These findings suggest a possible role for peri-transplant aspiration in PGD, a potentially actionable mechanism that warrants further investigation.