Chondroprotective Effects of a Single PRP Injection in a Spontaneous Osteoarthritis Model of Dunkin Hartley Guinea Pig: An Immunohistochemical Analysis.

Devendra Kumar ChouhanSandeep PatelTarkik ThamiNarayan Prasad MishraUma NaharMandeep Singh Dhillon

Published in: Indian journal of orthopaedics (2024)

The impact of a solitary injection of PRP on upregulation of anabolic pathways inside cartilage is relatively slower as compared to its effect on downregulation of apoptotic pathways. Even a single PRP injection holds the potential to change cartilage microenvironment, but the effects are not long lasting.

Keyphrases

platelet rich plasma
ultrasound guided
signaling pathway
cell death
stem cells
extracellular matrix
rheumatoid arthritis
poor prognosis
risk assessment