Management of toxic optic neuropathy via a combination of Wharton's jelly-derived mesenchymal stem cells with electromagnetic stimulation.
Emin ÖzmertUmut ArslanPublished in: Stem cell research & therapy (2021)
Toxic optic neuropathies are emergent pathologies that can result in acute and permanent blindness. After poisoning with toxic substances, progressive apoptosis continues in optic nerve axons and ganglion cells. After the proper first systemic intervention in intensive care clinic, the WJ-MSC and rEMS combination seems very effective in the short-term period in cases with TON. To prevent permanent blindness, a combination of WJ-MSC and rEMS application as soon as possible may increase the chance of success in currently untreatable cases. Trial Registration ClinicalTrials.gov ID: NCT04877067.
Keyphrases
- optic nerve
- cell cycle arrest
- optical coherence tomography
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- randomized controlled trial
- oxidative stress
- multiple sclerosis
- clinical trial
- primary care
- study protocol
- liver failure
- neuropathic pain
- drinking water
- spinal cord injury
- high frequency
- hepatitis b virus
- phase iii
- placebo controlled