Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia.
Shifaa M AbdinDaniela PaaschArnold KloosMarco Carvalho OliveiraMi-Sun JangMania AckermannAndriana StamopoulouPhilipp J MrochChristine S FalkConstantin S von KaisenbergAxel SchambachMichael HeuserThomas MoritzGesine HansenMichael MorganNico LachmannPublished in: Journal for immunotherapy of cancer (2023)
In summary, our work provides insights into the seminal use and behavior of CAR-macrophages which are derived from various sources of stem cells, while introducing a unique technology for CAR-macrophage manufacturing, all dedicated to the clinical translation of CAR-macrophages within the field of anticancer immunotherapies.