Wall shear stress-related plaque growth of lipid-rich plaques in human coronary arteries: an near-infrared spectroscopy and optical coherence tomography study.
Eline M J HartmanGiuseppe De NiscoAnnette M KokMariusz TomaniakFay M A NousSuze-Anne KortelandFrank J H GijsenWijnand K den DekkerRoberto DilettiNicolas M D A van MieghemJeroen M WilschutFelix ZijlstraAnton F W van der SteenRicardo P J BuddeJoost DaemenJolanda J WentzelPublished in: Cardiovascular research (2022)
This study demonstrates that NIRS- and OCT-detected lipid-rich regions exposed to low WSS are subject to enhanced plaque growth over a 1-year follow-up. The presence of lipids and low WSS proves to have a synergistic effect on plaque growth.