Genetic regulation of IL-8 influences disease presentation of multiple sclerosis.

Ettore DolcettiAntonio BrunoFederica AzzoliniLuana GilioLuigi PavoneEnnio IezziGiovanni GalifiStefano GambardellaRosangela FereseFabio ButtariFrancesca De VitoPaola ColantuonoRoberto FurlanAnnamaria FinardiAlessandra MusellaGeorgia MandolesiDiego CentonzeMario Stampanoni Bassi

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)

We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS.

Keyphrases

multiple sclerosis
genome wide
copy number
poor prognosis
mass spectrometry
dna methylation
white matter
ms ms
oxidative stress
binding protein
high density
genome wide identification
transcription factor