Antibodies Reactive to Leptin in Adults with Type 2 Diabetes and Its Relationship with Clinical, Metabolic and Cardiovascular Risk Parameters.

Ana B Vargas-AntillónMildren Porchas-QuijadaEloy A Zepeda-CarrilloRafael Torres-ValadezJosé Francisco Munoz-Valle Rafael Vázquez-Solórzano Elia Valdés-Miramontes Luis A Hernández-Palma Zyanya Reyes-Castillo

Published in: Endocrine research (2023)

The decrease of IgG anti-leptin immune complexes observed in patients with T2D and obesity suggests a reduction in antibody affinity to the hormone that may impact its transport and signaling, lipid, lipoprotein and insulin metabolism.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
weight gain
glycemic control
fatty acid
skeletal muscle
physical activity