Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma.

Heting Dong Yinying Ren Yiyi Song Wei Ji Yongdong Yan Canhong Zhu Li Huang Meijuan Wang Wenjing Gu Xinxing Zhang Huiming Sun Chuangli Hao Zhengrong Chen

Published in: Iranian journal of immunology : IJI (2024)

The treatment of anti-ICOSL effectively improved lung interstitial inflammation and mucus secretion in mice with neutrophilic asthma by restoring the balance of Th1/Th2/Th17 responses. These findings indicate that blocking the ICOS/ICOSL signaling could be an effective way to manage neutrophilic asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
oxidative stress
high fat diet induced
randomized controlled trial
air pollution
type diabetes
metabolic syndrome
wild type